Main Cast[edit]
- Ellen Pompeo as Dr. Meredith Grey
- Sandra Oh as Dr. Cristina Yang
- Katherine Heigl as Dr. Izzie Stevens (Until Episode 18)
- Justin Chambers as Dr. Alex Karev
- Chandra Wilson as Dr. Miranda Bailey
- James Pickens Jr. as Dr. Richard Webber
- Sara Ramirez as Dr. Callie Torres
- Eric Dane as Dr. Mark Sloan
- Chyler Leigh as Dr. Lexie Grey
- Kevin McKidd as Dr. Owen Hunt
- Jessica Capshaw as Dr. Arizona Robbins
- Kim Raver as Dr. Teddy Altman (From Episode 19)
- Patrick Dempsey as Dr. Derek Shepherd
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